PDF Developmental Nephrology: from Embryology to Metabolomics (Systems Medicine)

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Expert Opinion on Biological Therapy. European Journal of Clinical Investigation. Clinica Chimica Acta. Prostaglandins Leukotrienes and Essential Fatty Acids. Journal of Inflammation. Nitric Oxide - Biology and Chemistry.

Functional Genomics of Systemic Disorders

Amino Acids. American Journal of Translational Research. Hormone and Metabolic Research.

Lipids in Health and Disease. Pharmacology Biochemistry and Behavior. Cell Communication and Adhesion. Best Practice and Research in Clinical Haematology. Molecular and Cellular Biochemistry. Annals of Laboratory Medicine. Molecules , Clin Biochem Big data analysis is performed connecting immunoistochemistry and metabolomics in experimental models.

Finally we studied the long term cardio-renal effects of extreme prematurity on a cohort of apparently healthy adults born ELBW Bassareo PP. JPNIM The life of every individual is a continuum from prenatal life to adult see 2 books: Fanos V. Humana Press According with T. Renal stem cells in preterm kidney. From Faa G. J Pediatr Neonat Individual Med. Urinary metabolomics in newborn piglet model of asphyxia.

From: Murgia F, et al. Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations. Epigenetic modulation of kidney developemet. Kidney embryogenesis: how to look at old things with new eyes. In: Fanos V.

The NMF analysis indicated that one metagene F1 comprises genes which are highly expressed at only 5 days of culture when ZO1 is almost completely incorporated into the inextractable cytoskeletal fraction but not at 3 days of culture when ZO1 is almost fully extractable. These genes, mainly expressed after formation of elongated S-shaped bodies morphologically the last step before formation of the proximal tubule and other nephron segments, and correlating to the time period in which tight junction maturation was shown to occur based on biochemical criteria , seem likely to include those involved in the later post-MET steps in the differentiation of the proximal tubule.

IS New Directions In Neonatal Nephrology Research | Archives of Disease in Childhood

Thus, in cultured nephrons, biochemical and informatic analyses identify a time frame in which the earliest signs of this nephron segment differentiation are established. Increasing distance between the samples on the map corresponds to increasing difference in the abstracted transcriptome.

The arrow highlights metagene F1, which comprises genes highly expressed only after 5 days hours in culture. Having established a window for the maturation and differentiation of the proximal tubule between 3 and 5 days of culture , a global approach to identifying the genetic mechanisms regulating the functional maturation process was undertaken.

Several genes known to be contributors to the process of nephron segmentation are expressed at the S-shaped body stage of development, and ultimately affect the differentiation of the nephron. For instance, genetic deletion of the Brn1 gene causes a disruption in the differentiation of the Loop of Henle and the distal tubule, while Notch2 is required for proximal tubule fate [17] , [30].

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These genes, however, are two of only a few known genes that control nephron segment differentiation. While genes already known to play a key role in nephrogenesis do not alone provide new information about the differentiation of the proximal tubule, an expanded developmental program with potentially novel and important connections begins to emerge with the addition of potential interactors from relevant transcriptomic analyses. To move towards a transcriptome-wide understanding of the process of proximal tubule differentiation, microarray data from in vivo and ex vivo nephrons was analyzed.

Analysis of genes expressed in the developing nephron was done at two stages corresponding approximately to the s-shaped body and early proximal tubule based on the biochemical data described above. Those genes which significantly differed between 3 and 5 days in cultured MM were used as a set of potential interactions, since they correspond temporally to structural and marker-based nephron development and biochemically-defined tight junction maturation and functional transport of organic anions by the developing nephron see above.

Patrick C. Barth, MD.


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Julia Spencer Barthold, MD. Louis E. Bartoshesky, MD. Areas of Research: Genetics. Sonali P. Barwe, PhD.

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Jonathan E. Bennett, MD. Matthew R.

Benson, MD. Areas of Research: Endocrinology. Loren Berman, MD. Areas of Research: Pediatrics. Kathryn V.

Metabolite Identification and Annotation

Michael B. Bober, MD. Neil Boris, MD.